It doesn't matter how many relics you use (I think). I have earned 15 teeth playing solo and doing all the challenges and 14 using 4 relics. But with other players (co-op), I had done the very same things using 3 relics and helped them escape for the first time and I managed to get 9 teeth only. My opinion...just use one relic, do all challenges, don't let Cryptids damage the drill at all if it is possible, kill as many cryptids as you can, do a Platinum escape and personally I reccomend playing solo. I don't know how much this will help you but when I do this, i get about 15 teeth for sure.
Let us know if you find a way that we can gather as many teeth as possible. (excuse any mistakes but I don't speak English very well)
Actually, it does matter for relics. 6 is the cut off point though. So: 1 tooth for 1 relic, 2 teeth for 2 relics etc. but then if you use 7, 8, 9 or 10 relics, you still only get 6 teeth.
So in a regular game currently, you can get this for the game:
- 1 tooth for every 300 kills
- 1 tooth per relic (6 being max)
- 1 tooth from daily pool
- 3 teeth for the escape
- 2 for 10 challenges complete IN THAT GAME
- 4 additional teeth if you get completionist
So if you only get 1 for 300 kills, and lets say you get everything else except the bonus pool, and you use 6 relics, you should get 16 teeth.